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ABSTRACT Zinc is an essential micronutrient for plant metabolism and has been studied in several crops of economic interest. However, there is no evidence of its use in coconut crops. The objective of this study was to evaluate the influence of foliar zinc fertilization with doses of zinc on dwarf green coconut seedlings based on their nutritional status, growth attributes, and gas exchange. The experimental design consisted of randomized blocks, and the treatments consisted of different zinc doses (0, 5, 10, 15, 20, and 25 g per plant) with five replicates. Seedlings were positively influenced by zinc dose, mainly in terms of growth variables and gas exchange. Zinc fertilization reduced iron and manganese content and increased zinc concentrations in the leaf tissue. Zinc fertilization promoted an increase in leaf area, height, shoot dry mass, and total dry mass. Furthermore, zinc fertilization improved photosynthesis, transpiration, stomatal conductance, internal CO2 concentration, instantaneous water use efficiency, and intrinsic water use efficiency. The improvement in these growth indices and gas exchange, in most variables, was up to an estimated dose of approximately 16 g of zinc per plant and decreased with increasing doses.

RESUMO O zinco é um micronutriente de importância essencial para o metabolismo vegetal, é estudado para diversas culturas de interesse econômico, porém sem evidências de estudo para a cultura do coqueiro. Objetivou-se com este estudo avaliar a influência da fertilização com doses de zinco via foliar em mudas de coqueiro anão verde, por meio do estado nutricional, atributos de crescimento e trocas gasosas. O delineamento experimental foi em blocos ao acaso, e os tratamentos foram constituídos por doses de zinco (0, 5, 10, 15, 20 e 25 g por planta), com cinco repetições. As mudas foram influenciadas positivamente pelas doses de zinco principalmente nas variáveis de crescimento e nas trocas gasosas. No estado nutricional afetou de maneira decrescente o ferro e o manganês e aumentou o zinco no tecido foliar. O zinco proporcionou incrementos na área foliar, altura de plantas, massa seca da parte aérea e massa seca total. Além disso, melhorou a fotossíntese, transpiração, condutância estomática, concentração interna de CO2, eficiência instantânea do uso da água e eficiência intrínseca do uso da água. A melhora nesses índices de crescimento e trocas gasosas, na maioria das variáveis, foi até a dose estimada de aproximadamente 16 g de zinco por planta e diminuiu com o aumento das doses.

https://doi.org/10.1590/1807-1929/agriambi.v27n11p864-872

Impact of radiotherapy on the morphological and compositional structure of intra-radicular dentin
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Martini, Georgia Ribeiro

; Bortoluzzi, Eduardo A.

; Minamisako, Mariana C.

; Bordignon, Natalia C. Trentin

; Rodrigues, Paulo M.

; Gondak, Rogério

Brazilian Dental Journal

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Fev 2023, Volume 34 Nº 1 Páginas 45 - 51

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Considering the side effects in the oral cavity and dental structures of radiotherapy (RDT) for head and neck cancer, this study aimed to evaluate the effects of RDT on the root dentin concerning the obliteration of dentinal tubules, the inorganic composition of intra-radicular dentin, and the integrity of collagen fibers. Thirty human canines were selected from a biobank and randomly divided into two groups (n=15). The samples were sectioned buccolingually, and a hemisection was used for structural analysis by scanning electron microscopy (SEM) and energy-dispersive X-ray spectrometer (EDS). Low-vacuum SEM images were obtained at 2000-x magnification to observe the obliteration of the dentinal tubules. Moreover, compositional evaluation was performed using EDS. After RDT, the SEM and EDS analyses were repeated using the same methodology. RDT was applied fractionally at 2 Gy per day, 5 days per week, for 7 weeks, resulting in a total dose of 70 Gy. The collagen integrity of the irradiated and non-irradiated samples was analyzed using Masson’s trichrome and picrosirius red staining polarization microscopy. Samples subjected to RDT exhibited dentinal tubule obliteration (p < 0.001); low integrity of type I and III collagen fibers (p < 0.05); compositional reduction of calcium (p = 0.012), phosphorus (p = 0.001), and magnesium (p < 0.001); an increased Ca/P ratio (p < 0.001). RDT affects the structure of dentinal tubules, the inorganic composition of intra-radicular dentin, and the collagen fiber integrity in the root dentin, which may interfere with the effectiveness and durability of dental procedures.

Resumo Considerando os efeitos colaterais na cavidade oral e estruturas dentárias da radioterapia (RDT) para o câncer de cabeça e pescoço, este estudo teve como objetivo avaliar os efeitos da RDT sobre a dentina radicular quanto à obliteração dos túbulos dentinários, a composição inorgânica da dentina intra-radicular e a integridade das fibras colágenas. Trinta caninos humanos foram selecionados de um biobanco e divididos aleatoriamente em dois grupos (n=15). As amostras foram seccionadas no sentido vestíbulo-lingual, e uma hemissecção foi utilizada para análise estrutural por microscopia eletrônica de varredura (MEV) e espectrômetro de raios X de dispersão de energia (EDS). Imagens de MEV de baixo vácuo foram obtidas com aumento de 2500x para observar a obliteração dos túbulos dentinários. Além disso, a avaliação composicional foi realizada usando EDS. Após a RDT, as análises em MEV e EDS foram repetidas usando a mesma metodologia. A RDT foi aplicada fracionada a 2 Gy por dia, 5 dias por semana, durante 7 semanas, resultando em uma dose total de 70 Gy. A integridade do colágeno das amostras irradiadas e não irradiadas foi analisada usando microscopia de polarização de coloração com tricrômio de Masson e picrosirius red. As amostras submetidas a RDT apresentaram obliteração dos túbulos dentinários (p < 0,001); baixa integridade das fibras colágenas tipo I e III (p < 0,05); redução composicional de cálcio (p = 0,012), fósforo (p = 0,001) e magnésio (p < 0,001); e uma relação Ca/P aumentada (p < 0,001). A RDT afeta a estrutura dos túbulos dentinários, a composição inorgânica da dentina intra-radicular e a integridade das fibras colágenas na dentina radicular, o que pode interferir na eficácia e durabilidade dos procedimentos odontológicos.

https://doi.org/10.1590/0103-6440202305101

Prevalence of and risk factors for post-COVID: Results from a survey of 6,958 patients from Brazil
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TALHARI, CAROLINA

; CRIADO, PAULO R.

; CASTRO, CAIO C.S.

; IANHEZ, MAYRA

; RAMOS, PAULO M.

; MIOT, HÉLIO A.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Nº 1 elocation e20220143

Resumo: En | Texto: En | PDF: En

Abstract A plethora of prolonged COVID-19 symptoms, or late manifestations has been reported after acute disease and labeled “post-COVID”. The aim of this study was to identify the prevalence of and risk factors for post-COVID up to 12 weeks after the onset of acute COVID-19. An electronic survey was conducted to evaluate post-COVID-19 symptoms, disease severity, demographics, and pre-existing diseases. The participants were recruited through 88,648 SMS messages, and post on social media. The associations between variables were explored through multivariate models. From 6,958 respondents with confirmed COVID-19, 753 (10.8%) required hospitalization, and 5,791 (83.2%) exhibited at least one post-COVID manifestation. Hair loss (49.4%), memory loss (40.7%), low attention (37.0%), fatigue (34.2%), anxiety (31.2%), and headache (29.6%) were the most reported post-COVID manifestations. Female sex, myalgia, anosmia, and severe disease were associated with most post-COVID manifestations. Pre-existing depression was associated with the development of neuropsychiatric manifestations. Post-COVID manifestations were identified in most patients following COVID-19 infection, placing a supplementary burden on the healthcare system. Hair loss, fatigue, and neuropsychiatric symptoms were the most prevalent post-COVID manifestations. Female sex, myalgia, anosmia, and more severe disease are risk factors for multiple post-COVID manifestations.

https://doi.org/10.1590/0001-3765202320220143

PAHs impacts on aquatic organisms: contamination and risk assessment of seafood following an oil spill accident
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MELO, PAMELLA TALITA S.

; TORRES, JOÃO PAULO M.

; RAMOS, LEONARDO R.V.

; FOGAÇA, FABÍOLA HELENA S.

; MASSONE, CARLOS G.

; CARREIRA, RENATO S.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 elocation e20211215

Resumo: En | Texto: En | PDF: En

Abstract Oil spills, intrinsically related to the petroleum production chain, represent a risk to the marine environment and a potential threat to humans through seafood consumption. We revised the NE Brazil oil spill and other accidents along the Brazilian coast, with a focus on seafood contamination, covering topics such as bioaccumulation, bioaccessibility, and risk analysis. Comprehensive knowledge of the impacts of spills helps in the interpretation of the dynamics of hydrocarbons released into the sea, contributing to actions to control their negative impacts. Currently, no legal limits have been established permanently in Brazil for PAHs in seafood edible tissues.

https://doi.org/10.1590/0001-3765202220211215

Correlation of cGAS, STING, INF-α and INF-β gene expression with Zika virus kinetics in primary culture of microglia and neurons from BALB/c mice
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SOUZA, MAYQUE PAULO M. DE

; FREITAS, BÁRBARA CAROLINE G.

; HOLANDA, GUSTAVO M.

; DINIZ JUNIOR, JOSÉ ANTÔNIO P.

; CRUZ, ANA CECÍLIA R.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 elocation e20211189

Resumo: En | Texto: En | PDF: En

Abstract Pattern recognition receptors participate in the innate immune response. Among PRRs, the cGAS/STING pathway is known to detect cytosolic DNA and cyclic dinucleotides, but it’s also important in RNA virus infection. We aimed to evaluate the gene expression of some important genes of cGAS/STING pathway and to correlate this expression with Zika virus kinetics in mice microglia and neurons. Cells were infected by MOI = 1.0. Indirect immunofluorescence, plaque titration of supernatant, extraction, and quantification of total intracellular RNA, RT-qPCR and Western blotting were performed. Plaque titration profile in microglia and neurons was similar, including higher titers of plaque forming units at 24, 48, 72 and 96 hpi, respectively. ZIKV kinetics evaluated by RT-qPCR was similar in both cells, with highest viral titers at 48, 72, 24 and 96 hpi, respectively. Expression profile of cGAS, STING, INF-α and INF-β was quite different between the cells, including gene suppression, as observed for cGAS in neurons. Our results showed a differentiated expression profile of cGAS/STING pathway genes in mice microglia and neurons, which can be explained by the different mechanisms that ZIKV uses to bypass the immune response of these cells. Furthermore, each cell type responds differently to combat the viral infection.

https://doi.org/10.1590/0001-3765202220211189

COVID-19 in the Perioperative Period of Cardiovascular Surgery: the Brazilian Experience
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Gomes, Walter J.

; Rocco, Isadora

; Pimentel, Wallace S.

; Pinheiro, Aislan H. B.

; Souza, Paulo M. S.

; Costa, Luiz A. A.

; Teixeira, Marjory M. P.

; Ohashi, Leonardo P.

; Bublitz, Caroline

; Begot, Isis

; Moreira, Rita Simone L

; Hossne Jr, Nelson A.

; Vargas, Guilherme F.

; Branco, João Nelson R.

; Teles, Carlos A.

; Medeiros, Eduardo A. S.

; Sáfadi, Camila

; Rampinelli, Amândio

; Moratelli Neto, Leopoldo

; Rosado, Anderson Rosa

; Mesacasa, Franciele Kuhn

; Capriata, Ismael Escobar

; Segalote, Rodrigo Coelho

; Palmieri, Deborah Louize da Rocha Vianna

; Jardim, Amanda Cristina Mendes

; Vianna, Diego Sarty

; Coutinho, Joaquim Henrique de Souza Aguiar

; Jazbik, João Carlos

; Coutinho, Henrique Madureira da Rocha

; Kikuta, Gustavo

; Almeida, Zely Sant'Anna Marotti de

; Feguri, Gibran Roder

; Lima, Paulo Ruiz Lucio de

; Franco, Anna Carolina

; Borges, Danilo de Cerqueira

; Cruz, Felipe Ramos Honorato De La

; Croti, Ulisses Alexandre

; Borim, Bruna Cury

; Marchi, Carlos Henrique De

; Goraieb, Lilian

; Postigo, Karolyne Barroca Sanches

; Jucá, Fabiano Gonçalves

; Oliveira, Fátima Rosane de Almeida

; Souza, Rafael Bezerra de

; Zilli, Alexandre Cabral

; Mas, Raul Gaston Sanchez

; Bettiati Junior, Luiz Carlos

; Tranchesi, Ricardo

; Bertini Jr, Ayrton

; Franco, Leandro Vieira

; Fernandes, Priscila

; Oliveira, Fabiana

; Moraes Jr, Roberto

; Araújo, Thiago Cavalcanti Vila Nova de

; Braga, Otávio Penna

; Pedrosa Sobrinho, Antônio Cavalcanti

; Teixeira, Roberta Tavares Barreto

; Camboim, Irla Lavor Lucena

; Gomes, Eduardo Nascimento

; Reis, Pedro Horigushi

; Garcia, Luara Piovan

; Scorsioni, Nelson Henrique Goes

; Lago, Roberto

; Guizilini, Solange

Brazilian Journal of Cardiovascular Surgery

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Dez 2021, Volume 36 Nº 6 Páginas 725 - 735

Resumo: En | Texto: En | PDF: En

Abstract Introduction: We investigated the clinical course and outcomes of patients submitted to cardiovascular surgery in Brazil and who had developed symptoms/signs of coronavirus disease 2019 (COVID-19) in the perioperative period. Methods: A retrospective multicenter study including 104 patients who were allocated in three groups according to time of positive real time reverse transcriptase-polymerase chain reaction (RT-PCR) for the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2): group 1, patients who underwent cardiac surgery > 10 days after positive RT-PCR; group 2, patients with a positive RT-PCR within 10 days before or after surgery; group 3, patients who presented positive RT-PCR > 10 days after surgery. The primary outcome was mortality and secondary outcomes were postoperative complications, intensive care unit (ICU) length of stay, and postoperative days of hospitalization. Results: The three groups were similar with respect to age, the European System of Cardiac Operative Risk Evaluation score, and comorbidities, except hypertension. Postoperative complications and death were significantly higher in groups 2 and 3 than in group 1, and no significant difference between groups 2 and 3 was seen. Group 2 showed a high prevalence of surgery performed as an urgent procedure. Although no significant differences were observed in ICU length of stay, total postoperative hospitalization time was significantly higher in group 3 than in groups 1 and 2. Conclusion: COVID-19 affecting the postoperative period of patients who underwent cardiovascular surgery is associated with a higher rate of morbidity and mortality. Delaying procedures in RT-PCR-positive patients may help reduce risks of perioperative complications and death.

https://doi.org/10.21470/1678-9741-2021-0960

Chemical Constituents and Cytotoxic Activity of Rhinella jimi (Anura: Bufonidae)
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Monção Filho, Evaldo S.

; Pio, Yara P. F.

; Chaves, Mariana H.

; Ferreira, Paulo M. P.

; Fonseca, Mariluce G.

; Pessoa, Cláudia

; Lima, Daisy J. B.

; Araújo, Bruno Q.

; Vieira Jr., Gerardo M.

Journal of the Brazilian Chemical Society

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Mai 2021, Volume 32 Nº 5 Páginas 1060 - 1069

Resumo: En | Texto: En | PDF: En

Rhinella jimi toads (Stevaux, 2002) belong to the Bufonidae family, are endemic in the Brazilian Northeast and are commonly found during rainy periods. In general, amphibians of this family have in their poisons different metabolites that show a diversity of pharmacological activities. The isolation and identification of these compounds are of great importance, and techniques such as high-performance liquid chromatography coupled to mass spectrometry are widely used for the discovery of novel and known compounds in these poisons. For R. jimi poison, the ethyl acetate and methanolic extracts were obtained and thirty compounds were identified by combining ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-MS) with direct infusion atmospheric pressure chemical ionization mass spectrometry (DI-APCI-MS/MS) and direct infusion electrospray mass spectrometry (DI-ESI-MS/MS) for each extract, respectively. Marinobufagin (2) and marinobufotoxin (19) were the majorities of each extract, respectively. In addition, other bufadienolides mainly present in the ethyl acetate extract, such other bufotoxins, alkaloids and arginine diacid derivatives were identified in the methanol extract. In a cytotoxic assay by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), the extracts and compound 2 demonstrated half-maximal inhibitory concentration (IC50) values better than the positive control doxorubicin, evidencing excellent cytotoxic. This is the most complete study of the chemical composition of R. jimi toad poison and its respective cytotoxic activity, promoting the enrichment of knowledge about this family and species.

https://doi.org/10.21577/0103-5053.20210009 133 downloads

Efficacy and safety of sorafenib in elderly patients with advanced hepatocellular carcinoma
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Marta, Guilherme Nader

; da Fonseca, Leonardo G.

; Braghiroli, Maria Ignez

; Moura, Fernando

; Hoff, Paulo M.

; Sabbaga, Jorge

Clinics

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2021, Volume 76 elocation e2498

Resumo: En | Texto: En | PDF: En

OBJECTIVES: To evaluate the efficacy and safety of sorafenib in elderly patients with advanced hepatocellular carcinoma (HCC). METHODS: We analyzed data from a cohort of patients with advanced HCC treated using systemic treatment according to the local institutional protocol. Patients were divided into two groups, Group A, individuals <70 years of age, and Group B, individuals 70 years of age or older at the time of treatment initiation. Efficacy, measured based on overall survival (OS) and time to treatment failure (TTF), and toxicity were compared between groups. RESULTS: A total of 238 patients with advanced HCC who received sorafenib between 2007 and 2018 were evaluated. The median age for Group A was 59.1 years and that for Group B 73.6 years. The major prognostic characteristics were balanced between the groups. There were no significant differences in OS between Group A (8.0 months, 95%CI 6.34-9.3) and Group B (9.0 months, 95%CI 5.38-12.62), p=0.433, or in TTF between Group A (3.0 months, 95%CI 2.39-3.60) and Group B (3.0 months, 95%CI 1.68-4.32), p=0.936. There were no significant differences between Groups A and B with respect to the incidence of adverse events or treatment discontinuation because of toxicity. CONCLUSION: Efficacy and safety of sorafenib did not differ significantly between younger and older patients with HCC. Our data suggest that age alone should not restrict clinical decision-making for patients with advanced HCC.

https://doi.org/10.6061/clinics/2021/e2498 515 downloads

Phase II trial of humanized anti-Lewis Y monoclonal antibody for advanced hormone receptor-positive breast cancer that progressed following endocrine therapy
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Testa, Laura

; Mano, Max

; Arai, Roberto Jun

; Bonadio, Renata Colombo

; Serrano, Sergio V.

; Zorzetto, Marina M Costa

; Crocamo, Susanne

; Smaletz, Oren

; Freitas-Junior, Ruffo

; Hoff, Paulo M.

Clinics

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2021, Volume 76 elocation e3146

Resumo: En | Texto: En | PDF: En

OBJECTIVES: The Lewis-Y antigen is expressed in 44%-90% of breast cancers (BCs). The expression of the antigen in carcinoma tissue differs from that in normal tissues. This study aimed to evaluate the clinical benefit of the humanized anti-Lewis Y monoclonal antibody, hu3S193, in advanced hormone receptor-positive and Lewis Y-positive BC after administration of endocrine therapy (ET). METHODS: A single-arm phase II study was conducted in seven centers. Patients with advanced hormone receptor-positive BC who failed first-line ET were included. The inclusion criterion was the observation of tumoral expression of the Lewis Y antigen during immunohistochemistry. The treatment comprised hu3S193 antibody administration at weekly intravenous doses of 20 mg/m2 for 8-week cycles. The primary endpoint was the clinical benefit rate. ClinicalTrials.gov NCT01370239. RESULTS: The study stopped accrual following an unplanned interim analysis as the hu3S193 antibody lacked sufficient activity to justify continuation of the study. Twenty-two patients were enrolled, of whom 21 were included in the efficacy analysis. The clinical benefit rate was 19%, with four patients presenting with stable disease after 24 weeks. One patient with prolonged stable disease received medication for over 2 years. No partial or complete responses were observed. The median time to progression and overall survival was 5.4 and 37.5 months, respectively. CONCLUSIONS: The humanized anti-Lewis Y monoclonal antibody, hu3S193, exhibited insufficient activity in this cohort. However, the possibility of activity in a more strictly selected subgroup of patients with higher levels of Lewis Y tumoral expression cannot be overlooked.

https://doi.org/10.6061/clinics/2021/e3146 110 downloads

10.

Uma tradução comentada do artigo “A Termodinâmica Oculta das Partículas” de Louis de Broglie
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Lima, Nathan W.

; Chaib, João Paulo M. C.

Revista Brasileira de Ensino de Física

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2021, Volume 43 elocation e20210246

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Louis de Broglie é principalmente lembrado por sua contribuição no que se refere à dualidade onda-partícula e à expressão que relaciona o momento linear e o comprimento de onda no desenvolvimento da Teoria Quântica, contribuições dadas no período de 1922–1924. Entretanto, pouco se fala de sua postura e atividade crítica a interpretações afins da Complementaridade de Niels Bohr, e sua proposta de novas bases para uma teoria quântica alternativa, de caráter realista e determinista. Assim, no sentido de apresentar textos históricos originais e contribuir para o resgate das ideias de Louis de Broglie, apresentamos uma tradução comentada do artigo “A Termodinâmica Oculta das Partículas”, publicado em 1964, em que de Broglie sintetiza sua proposta teórica e apresenta dois resultados importantes, a saber: que o caminho de menor ação percorrido por uma partícula é aquele que maximiza a entropia do meio subquântico; e que os estados de transição em um átomo teria uma entropia menor do que os estados estacionários, justificando termodinamicamente porque os estados estacionários têm maior probabilidade de acontecerem.

Louis de Broglie is mainly remembered for his contribution regarding the wave-particle duality and the expression that relates linear momentum and wavelength in the development of Quantum Theory, contributions given in the period 1922–1924. However, little is said about his posture and critical activity to related interpretations of Niels Bohr’s Complementarity, and his proposal of new bases for an alternative quantum theory, with a realistic and deterministic character. Thus, in order to present original historical texts and contribute to the rescue of Louis de Broglie’s ideas, we present a commented translation of the article “The Hidden Thermodynamics of Particles”, published in 1964, where de Broglie summarizes his theoretical proposal and presents two important results, namely: that the path of least action taken by a particle is the one that maximizes the entropy of the subquantum medium; and that transition states in an atom would have a lower entropy than steady states, thermodynamically justifying why steady states are more likely to happen. Tradução do resumo para o inglês.

https://doi.org/10.1590/1806-9126-rbef-2021-0246 127 downloads

11.

Câncer e Doenças Cardiovasculares na Pandemia de COVID-19
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Kawahara, Lucas Tokio

; Costa, Isabela Bispo Santos da Silva

; Barros, Cecília Chie Sakaguchi

; Almeida, Gabriel Coelho de

; Bittar, Cristina Salvadori

; Rizk, Stephanie Itala

; Testa, Laura

; Moniz, Camila Motta Venchiarutti

; Pereira, Juliana

; Oliveira, Gláucia Maria Moraes de

; Diz, Maria Del Pilar Estevez

; Guimarães, Patricia Oliveira

; Pinto, Ibraim Masciarelli

; Kalil Filho, Roberto

; Hajjar, Ludhmila Abrahão

; Hoff, Paulo M.

Arquivos Brasileiros de Cardiologia

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Set 2020, Volume 115 Nº 3 Páginas 547 - 557

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O desafio imposto ao sistema de saúde pela pandemia da COVID-19 faz com que haja uma necessidade de readequações de rotinas e serviços de saúde, com os objetivos de controlar a disseminação do vírus e preservar a saúde. Torna-se ainda mais importante o manejo seguro e correto dos pacientes dos grupos de risco, como os pacientes idosos, os portadores de doenças cardiovasculares e os pacientes com câncer. Dessa forma, a cardio-oncologia ganha novo dimensionamento, no intuito de se adequar às necessidades dos pacientes diante de uma pandemia, reestruturando o sistema de atendimento de forma a oferecer qualidade e segurança na assistência à saúde.

Abstract The challenges that the COVID-19 pandemic cretead to the healthcare system have made it necessary to adapt routines and services, with the objectives of controlling the spread of the virus and preserving health. Safe and correct management of patients in risks groups, such as elderly patients, patients with cardiovascular diseases, and patients with cancer, has become even more important. Thus, cardio-oncology has gained a new dimension, with the aim of adapting to patients’ needs during the pandemic by restructuring the system of care in a manner that offers quality and safety in healthcare.

https://doi.org/10.36660/abc.20200405 4400 downloads

12.

Pandemia pela Covid-19 e multilateralismo: reflexões a meio do caminho
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BUSS, PAULO M.

; ALCÁZAR, SANTIAGO

; GALVÃO, LUIZ AUGUSTO

Estudos Avançados

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Ago 2020, Volume 34 Nº 99 Páginas 45 - 64

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O presente artigo analisa, de forma preliminar, as principais posições e respostas de instituições-chave do sistema multilateral das Nações Unidas, como a Assembleia Geral (AGNU) e a Secretaria Geral, e sua agência especializada em saúde, a Organização Mundial da Saúde (OMS), quanto à pandemia pela Covid-19, no período compreendido entre janeiro e maio de 2020. Usando como metodologia a análise de conteúdo dos principais documentos produzidos no âmbito do referido sistema multilateral, identifica a amplitude dessa abordagem, mas também seus limites, assim como os conflitos inerentes a um mundo dividido, que traduzem as disputas de atores políticos relevantes da cena mundial, transferidas também para o campo da saúde global. Ao final, aponta questões fundamentais a serem resolvidas no âmbito de um multilateralismo fraturado e enfraquecido.

ABSTRACT This article makes a preliminary analysis of the main positions and responses to covid-19 of the United Nations system and its main bodies, including the General Assembly, the Secretariat, and the World Health Organization. The article covers the period from January to May, 2020 and uses a methodology based on reading the content of the main documents issued by the UN system, and identifies the scope and limits of the approach taken, the conflicts inherent to a divided world and the disputes of political figures that take their differences to the area of global health. The article closes with a brief consideration of what is to come in a fractured and weakened multilateralism.

https://doi.org/10.1590/s0103-4014.2020.3499.004 8281 downloads

13.

Diseases of wild birds in southern Rio Grande do Sul, Brazil
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Echenique, Joanna V.Z.

; Soares, Mauro P.

; Albano, Ana Paula N.

; Bandarra, Paulo M.

; Schild, Ana Lucia

Pesquisa Veterinária Brasileira

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Fev 2020, Volume 40 Nº 2 Páginas 121 - 128

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Foi realizado um estudo retrospectivo dos diagnósticos de causas de morte e de lesões em aves silvestres na região Sul do Rio Grande do Sul de 2000 a 2018. Foram revisados os protocolos de necropsia e materiais de aves silvestres encaminhados ao Laboratório Regional de Diagnóstico da Faculdade de Veterinária da Universidade Federal de Pelotas no período. Foram recebidos 381 cadáveres para necropsia, 25 órgãos refrigerados e/ou em formol e 7 biopsias, totalizando 413 materiais. A maioria desses materiais foi remetida pelo Núcleo de Reabilitação da Fauna Silvestre da Universidade Federal de Pelotas (NURFS-CETAS-UFPel) e provenientes de municípios da área de influência do LRD-UFPel. Dos 413 casos 55 (13,31%) corresponderam a doenças metabólicas/nutricionais; 50 (12,10%) a traumas; 35 (8,47%) a doenças bacterianas/toxi-infecções; 30 (7,26%) a doenças parasitárias; 28 (6,77%) doenças fúngicas; 4 (0,97%) doenças virais e 17(4,12%) outras doenças que não se encaixavam nas categorias. Ainda em nos casos em que não foi possível determinar a etiologia, apresentaram autólise acentuada ou foram inconclusivos somaram 194 (46,97%). As doenças metabólicas/nutricionais e lesões traumáticas foram as principais causas de morte de aves silvestres, sendo a ordem mais afetada a Passeriformes.

ABSTRACT: Necropsy protocols of the “Laboratório Regional de Diagnóstico” of “Faculdade de Veterinária” of the “Universidade Federal de Pelotas” were reviewed, ranging the period from 2000 to 2018. Three hundred eighty one necropsies, 25 refrigerated and/or formaline fixed organs, and seven biopsies were received, representing 413 samples. Most of these materials were sent by the “Núcleo de Reabilitação da Fauna Silvestre” of “Universidade Federal de Pelotas” (NURFS-CETAS-UFPel) and were from municipalities within the range area of LRD-UFPel influence. Of the 413 cases 55 (13.31%) corresponded to metabolic/nutritional diseases; 50 (12.10%) to trauma; 35 (8.47%) to bacterial diseases/toxi-infections; 30 (7.26%) to parasitic diseases; 28 (6.77%) to fungal diseases; four (0.97%) to viral diseases and 17 (4.11%) to other diseases. Cases where it was not possible to determine the etiology, were in severe autolysis or were inconclusive totaled 194 (46.97%). Metabolic/nutritional diseases and traumatic injuries were the main cause of death in wild birds’, being Passeriformes the most affected order.

https://doi.org/10.1590/1678-5150-pvb-6409 1078 downloads

14.

Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)
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da Silva, Felipe Moura A

; da Silva, Katia Pacheco A

; de Oliveira, Luiz Paulo M

; Costa, Emmanoel V

; Koolen, Hector HF

; Pinheiro, Maria Lúcia B

; de Souza, Antonia Queiroz L

; de Souza, Afonso Duarte L

Memórias do Instituto Oswaldo Cruz

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2020, Volume 115 elocation e200207

Resumo: En | Texto: En | PDF: En

BACKGROUND Since the World Health Organization (WHO) declared Coronavirus disease 2019 (COVID-19) to be a pandemic infection, important severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural proteins (nsp) have been analysed as promising targets in virtual screening approaches. Among these proteins, 3-chymotrypsin-like cysteine protease (3CLpro), also named main protease, and the RNA-dependent RNA polymerase (RdRp), have been identified as fundamental targets due to its importance in the viral replication stages. OBJECTIVES To investigate, in silico, two of the most abundant flavonoid glycosides from Dysphania ambrosioides; a medicinal plant found in many regions of the world, along with some of the putative derivatives of these flavonoid glycosides in the human organism as potential inhibitors of the SARS-CoV-2 3CLpro and RdRp. METHODS Using a molecular docking approach, the interactions and the binding affinity with SARS-CoV-2 3CLpro and RdRp were predicted for quercetin-3-O-rutinoside (rutin), kaempferol-3-O-rutinoside (nicotiflorin) and some of their glucuronide and sulfate derivatives. FINDINGS Docking analysis, based on the crystal structure of 3CLpro and RdRp, indicated rutin, nicotiflorin, and their glucuronide and sulfate derivatives as potential inhibitors for both proteins. Also, the importance of the hydrogen bond and π-based interactions was evidenced for the presumed active sites. MAIN CONCLUSIONS Overall, these results suggest that both flavonoid glycosides and their putative human metabolites can play a key role as inhibitors of the SARS-CoV-2 3CLpro and RdRp. Obviously, further researches, mainly in vitro and in vivo experiments, are necessary to certify the docking results reported here, as well as the adequate application of these substances. Furthermore, it is necessary to investigate the risks of D. ambrosioides as a phytomedicine for use against COVID-19.

https://doi.org/10.1590/0074-02760200207 2439 downloads

15.

A simple fully nonlinear Kirchhoff-Love shell finite element
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Sanchez, Matheus L.

; Silva, Catia Costa e

; Pimenta, Paulo M.

Latin American Journal of Solids and Structures

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2020, Volume 17 Nº 8 elocation e325

Resumo: En | Texto: En | PDF: En

Abstract The current paper implementates a simple fully non-linear Kirchhoff-lovel shell penalty based finite element. The 6 nodes and 21 DoF triangular element developed in this work has a quadratic displacement field associated to it and the C1 continuity required by Kirchhoff-Love Hyphotesis is approximated by an internal penalty. The biggest novelty in this article is the simultaneous use of penalty and a Rodrigues incremental Rotation parameter (scalar DOF) between neighboring elements further explained in the text. The nonlinear finite element model developed in this article is compared to analytical results, commercial finite element code and another FEM model developed in bibliography. Simulations have demonstrated consistency when comparing results to other models and it is deemed that reliable mesh generation together with a powerfull triangular finite element is a good option for trustworthy thin shell simulations.

https://doi.org/10.1590/1679-78256120 409 downloads

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